Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma herbal pair restores intestinal mucosal barrier function in ulcerative colitis via activating Epac1/Rap1 pathway and inhibiting PI3K/AKT pathway
8 hours ago
- #intestinal barrier
- #ulcerative colitis
- #herbal medicine
- Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma (AR-AM) herbal pair helps restore intestinal mucosal barrier function in ulcerative colitis (UC).
- The study used a murine UC model induced by dextran sodium sulfate (DSS) to evaluate the therapeutic effects of AR-AM ethanolic extract (EEAR-AM).
- EEAR-AM significantly improved symptoms like weight loss, colon shortening, and disease activity index (DAI) in UC mice.
- It restored colonic tissue structure, reduced inflammation, and enhanced mucin MUC2 and tight junction protein expression.
- Network pharmacology suggested EEAR-AM modulates the Epac1/Rap1 and PI3K/AKT pathways to improve intestinal barrier function.
- Western blotting confirmed EEAR-AM activates Epac1/Rap1 while inhibiting PI3K/AKT in both UC mice and Caco-2 cells.