Targeting the PGRN-BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis - PubMed
4 hours ago
- #immunometabolism
- #lysosome
- #nanoparticle
- Chronic septic arthritis involves intracellular bacterial persistence and macrophage immunometabolic reprogramming.
- PGRN (progranulin) maintains lysosomal homeostasis by interacting with BMP (bis(monoacylglycero)phosphate).
- PGRN deficiency disrupts lysosomal integrity, induces immunosuppressive polarization, and aids bacterial immune evasion.
- NPs@PGRN, a dual-targeting nanoparticle system, restores lysosomal bactericidal capacity and reduces bacterial burdens.
- NPs@PGRN reprograms macrophage immunophenotypes toward antimicrobial competence.
- The study highlights lipid-immune crosstalk in chronic joint infection and offers a novel therapeutic strategy.