CDKL5 modulates the plasticity of excitatory synapses via liquid-liquid phase separation - PubMed
3 days ago
- #CDKL5
- #synaptic plasticity
- #liquid-liquid phase separation
- CDKL5 regulates excitatory synapse plasticity via liquid-liquid phase separation (LLPS).
- CDKL5 forms cocondensates with PSD95, organizing synaptic components and recruiting Kalirin7 for dendritic spine enlargement.
- Pathogenic mutations in CDKL5 impair LLPS, linking phase separation defects to CDKL5 deficiency disorder (CDD).
- The study highlights LLPS as a key mechanism in synaptic remodeling and PSD architecture reorganization.