Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation - PubMed
a day ago
- #immune reconstitution
- #hematopoietic stem cell transplantation
- #uterus transplantation
- Study investigates reconstitution of the human uterine immune system post uterus or hematopoietic stem cell transplantation (HSCT).
- Single-cell RNA sequencing and flow cytometry used to determine donor vs. recipient cell origin in the endometrium.
- Endometrial immune cell reconstitution observed after both uterus transplant and HSCT at transcriptomic, phenotypic, and spatial levels.
- Recipient-derived immune cells replaced donor cells post uterus transplant; HSCT led to near-complete donor-derived immune reconstitution.
- Tacrolimus-induced calcineurin-mediated inhibition of NFAT pathway did not prevent immune reconstitution, including tissue-resident lymphocytes.
- One case showed immune cells of male origin reconstituting the endometrium post HSCT.
- Findings provide insights into tissue immune system persistence and reconstitution in the uterus, an organ with continuous regeneration.