Porphyromonas gingivalis induces intestinal inflammation through gingipain-dependent gut microbiome dysbiosis - PubMed
5 hours ago
- #Periodontal pathogen
- #Intestinal inflammation
- #Gut microbiome
- Oral administration of Porphyromonas gingivalis (Pg) worsens intestinal inflammation in mice by disrupting the gut microbiome and boosting Th17 cells and pro-inflammatory cytokines.
- Gingipains, virulence factors of Pg, are crucial for inducing inflammation; knockout of all three gingipain genes significantly reduces inflammatory effects.
- Co-housing experiments show that gut microbiota remodeling can protect against Th17-driven inflammation, and immunization with inactivated Pg prevents dysbiosis and related inflammation.