Non-Invasive Assessment of Complete Regression in Endometrial Cancer Patients Undergoing Fertility Preservation Using MRI-Based Radiomics and Immune Heterogeneity - PubMed
2 days ago
- #radiomics
- #fertility-preservation
- #endometrial-cancer
- Non-invasive tool developed using MRI-based radiomics and immune heterogeneity to predict complete regression (CR) in endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) patients undergoing fertility-preserving treatment (FPT).
- Radiomics-clinical nomogram showed high predictive performance with AUC values of 0.963 (training) and 0.986 (validation).
- High radiomics score group had lower CR rates and exhibited immune alterations like reduced CD8+ T-cells and elevated M2 macrophages.
- Bulk RNA sequencing revealed upregulated oxidative phosphorylation and lipid metabolism pathways, indicating a metabolically active and immunosuppressive tumor microenvironment.
- Potential for guiding individualized FPT strategies for AEH and early EC patients.