ANGPTL4 Induces Aberrant Lymphatic-Like Remodeling in Proliferative Diabetic Retinopathy - PubMed
12 hours ago
- #ANGPTL4
- #Anti-VEGF Therapy
- #Diabetic Retinopathy
- ANGPTL4 is elevated in the vitreous humor of patients with proliferative diabetic retinopathy (PDR) who respond poorly to anti-VEGF therapy.
- The C-terminal fragment of ANGPTL4 induces retinal lymphatic-like remodeling in diabetic mice.
- The study provides new insights into immune activation, neovascularization, and lymphatic-like remodeling in PDR.
- Findings suggest ANGPTL4 as a potential therapeutic target for PDR, especially in anti-VEGF-resistant cases.