IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma - PubMed
4 hours ago
- #neutrophils
- #sarcoma
- #IL-1R2
- IL-1R2 deficiency reduces sarcoma growth but not other cancers like colorectal or lung cancer.
- IL-1R2 deficiency leads to increased neutrophil infiltration, neutrophilia, and emergency granulopoiesis in tumors.
- Neutrophils are crucial for tumor control in IL-1R2-deficient mice, showing higher activation and antitumor gene expression.
- In sarcoma patients, IL-1R2 deficiency gene signature correlates with better clinical outcomes.
- The study highlights IL-1R2's role in tuning IL-1-driven neutrophil activation towards an antitumor mode in sarcomas.