Molecular mechanisms in endometriosis: linking JAK/STAT pathway, ferroptosis, and microbial dysbiosis - PubMed
7 days ago
- #JAK/STAT
- #Endometriosis
- #Ferroptosis
- Endometriosis is a chronic gynecological disorder with ectopic endometrial growth, inflammation, pain, and infertility.
- Current hormonal and surgical therapies have limited efficacy and may compromise fertility.
- Gut microbiota dysbiosis and iron overload contribute to endometriosis pathophysiology.
- Excess iron may induce ferroptosis, a form of lipid peroxidation-driven cell death that amplifies inflammation.
- Cytokine-mediated JAK/STAT signaling, particularly IL-6/STAT3, integrates signals from immune cells, ferroptosis, and microbial metabolites.
- The microbiota-ferroptosis-JAK/STAT interaction network is proposed as an interconnected system sustaining inflammation in endometriosis.
- Exploring these pathways may lead to new microbiota- and ferroptosis-informed therapeutic strategies that preserve fertility.