Pancreatic-targeted lipid nanoparticles based on organ capsule filtration - PubMed
3 hours ago
- #Pancreatic-targeted delivery
- #Genome editing
- #mRNA therapeutics
- Development of pancreatic-targeted lipid nanoparticles (AH-LNP) for mRNA delivery.
- AH-LNP shows size enlargement with proteins, aiding pancreas-selective accumulation and receptor-mediated endocytosis.
- Enables precise genome editing in the pancreas using Cas9 mRNA and sgRNA for treating autoimmune pancreatic diseases.
- Demonstrates superior antitumor efficacy in pancreatic cancer models when combined with cancer vaccine or CAR-T therapy.
- Validated for safety and efficacy in multiple animal models, including non-human primates, indicating clinical translation potential.