Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound - PubMed
4 hours ago
- #Metformin
- #Multiomic analysis
- #HIV rebound
- Multiomic analysis identifies mechanisms controlling HIV rebound post-ART interruption.
- Delayed HIV rebound not linked to intact HIV but to specific immune effectors.
- mTOR inhibitor DDIT4 and ZNF254 associated with delayed rebound in CD4+ T cells.
- Metformin induces DDIT4, suppresses HIV expression, suggesting potential repurposing for HIV treatment.
- Supports immune- and HIV-silencing strategies for ART-free HIV remission.