Si-Jun-Zi-Tang potentiates temozolomide's anti-melanoma efficacy and reduces its hepatotoxicity - PubMed
4 hours ago
- #Hepatoprotection
- #Melanoma treatment
- #Chinese medicine
- Si-Jun-Zi-Tang (SJZT) enhances temozolomide (TMZ) anti-melanoma efficacy by promoting apoptosis and DNA damage in melanoma cells.
- SJZT reduces TMZ-induced hepatotoxicity by restoring bile acid homeostasis, reversing changes in bile salt transporters and detoxifying enzymes.
- Mechanistically, SJZT inhibits Chk1 and promotes MGMT proteasomal degradation, enhancing TMZ's anti-cancer effects.
- In vivo studies show SJZT boosts TMZ's anti-tumor effects while mitigating liver toxicity in melanoma-bearing mice.
- SJZT is a promising adjuvant therapy for melanoma, improving TMZ treatment outcomes and safety.