The Stress-Myopia Pathway: A Pivotal Hub in Myopia Pathogenesis - PubMed
4 hours ago
- #Myopia Pathogenesis
- #Neuroendocrine Disorders
- #Stress Response
- The paper introduces the 'stress-myopia pathway' hypothesis, suggesting that various risk factors act as stressors driving myopia progression through a chronic stress response, creating a vicious cycle.
- Chronic stress activates the HPA axis and SAM system, leading to neuroendocrine disorders, autonomic nervous system dysregulation, oxidative stress, inflammation, and other alterations linked to scleral remodeling and refractive changes.
- Potential multimodal strategies for managing stress responses include non-invasive vagus nerve stimulation, behavioral therapy, antioxidants, and gut microbiota therapy, offering promise for myopia prevention and control.