Comparative Efficacy of Surgical Versus Nonsurgical Management for Acute Achilles Tendon Rupture in a Novel Mouse Model - PubMed
a day ago
- #mouse model
- #surgical vs nonsurgical
- #Achilles tendon rupture
- Study compares surgical and nonsurgical management for acute Achilles tendon rupture in mice.
- Surgical repair with Kessler suture and nonsurgical tenotomy were tested with ankle immobilization at 160° (plantar flexion) or 90° (neutral alignment).
- At 2 weeks, surgical repair with 160° immobilization showed higher failure force and stiffness than nonsurgical groups, but no difference at 4 weeks.
- 160° immobilization groups had significantly higher failure force than 90° groups.
- Histological analysis showed better collagen alignment and higher COL1A1 expression in surgical groups.
- qPCR revealed higher expression of tendon repair genes (Scx, Tnmd, Tgfb1) in surgical groups, while inflammatory factors (Il1b, Il6) were higher in nonsurgical 90° group.
- Scx+ tendon progenitor stem cells were most prevalent in surgical 160° group.
- Both treatments achieved satisfactory healing with maximum plantar flexion, but surgical repair had superior histological outcomes.
- Clinical relevance suggests immobilization in maximum plantar flexion post-surgery may optimize tendon healing.