Mesenchymal stem cell-derived extracellular vesicles in the treatment of type 2 diabetes and its complications: current progress and future directions - PubMed
3 hours ago
- #Type 2 Diabetes
- #Extracellular Vesicles
- #Stem Cell Therapy
- MSC-EVs show potential in treating T2D and its complications by modulating inflammation, aiding tissue regeneration, and improving insulin resistance.
- Engineering strategies for MSC-EVs, such as optimizing culture conditions and modifying contents, enhance therapeutic efficacy and yield.
- Challenges include limited yield, heterogeneity of natural MSC-EVs, and safety and production issues for engineered MSC-EVs.
- Artificial intelligence is highlighted as a tool to guide future research directions for MSC-EV clinical translation.