Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4 - PubMed

3 days ago

ASXL1 is a key driver in various cancers and shows genetic correlation with BRD4.
The extraterminal domain of BRD4 forms a tight complex with ASXL1's BRD4-binding motif.
BRD4 recruitment to ASXL1 genomic targets depends on their interaction.
Cancer-related ASXL1 truncated variants (ASXL11-645 and ASXL11-591) retain BRD4 binding, with ASXL11-645 enhancing BRD4 recruitment.
ASXL11-645 interacts with both BRD4 and H3K4-specific methyltransferases MLL3/4, unlike ASXL11-591 which lacks MLL3/4 binding.
Genomic data from six cancer types shows a strong ASXL1-BRD4 relationship, suggesting a feed-forward mechanism.
The study elucidates the mechanistic association between ASXL1 and BRD4, highlighting its biological significance.

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