Pretreatment MRI as a Prognostic Factor After Radical Prostatectomy: A Systematic Review and Meta-Analysis - PubMed
5 hours ago
- #MRI
- #Prostate Cancer
- #Prognosis
- Pre-treatment MRI provides independent prognostic value for outcomes after radical prostatectomy.
- Extraprostatic extension (mrT3a) detected by MRI is associated with increased risk of biochemical recurrence (HR 2.16), metastatic failure (HR 3.18), and prostate cancer-specific mortality (HR 10.93).
- Seminal vesicle invasion (mrT3b) detected by MRI is associated with increased risk of biochemical recurrence (HR 2.74) and metastatic failure (HR 5.58).
- Quantitative MRI features prognostic for biochemical recurrence include PI-RADS score 4-5 (HR 2.15), tumor diameter ≥20mm (HR 2.35), and low ADC values (<0.9 × 10-3 mm2/s; HR 2.39).
- The analysis included 40 studies with 24,941 patients and found moderate heterogeneity and no significant publication bias.