Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting - PubMed
3 hours ago
- #mitotic spindle
- #cancer biology
- #chromosome segregation
- Polar chromosomes are prone to missegregation and micronuclear entrapment, contributing to chromosomal instability in cancer.
- Spindle elongation-driven microtubule pivoting is crucial for rescuing polar chromosomes from missegregation.
- Kinetochores on polar chromosomes form mono-lateral attachments, recruiting specific components but lacking Astrin.
- Modulating Eg5/KIF11 activity demonstrates that spindle elongation determines the direction and extent of microtubule pivoting.
- Limited spindle elongation in cancer cell lines delays polar chromosome resolution, while enhanced elongation accelerates it.
- The study provides mechanistic insight into chromosome congression errors in cancer.