Clinical Implications of Minipuberty - PubMed
3 hours ago
- #Minipuberty
- #Reproductive health
- #HPG axis
- Minipuberty is a period of high hypothalamic-pituitary-gonadal (HPG) axis activity in early postnatal life.
- In infant boys, high levels of FSH and LH lead to elevated gonadal hormones like testosterone and inhibin B.
- Infant girls also show HPG axis activity with adult levels of FSH and LH during minipuberty.
- The HPG axis becomes inactive after minipuberty until puberty begins.
- Minipuberty provides a diagnostic window for disorders like congenital hypogonadotropic hypogonadism.
- It can guide therapeutic interventions, including gonadotropin therapy.
- Minipuberty is predictive of adult reproductive capacity.