Mendelian randomization studies in atopic dermatitis: causal insights across omics layers - PubMed
4 hours ago
- #Mendelian randomization
- #Precision medicine
- #Atopic dermatitis
- Atopic dermatitis (AD) is a chronic inflammatory skin disease influenced by genetic, immune, and environmental factors.
- Mendelian randomization (MR) is a powerful tool for establishing causal relationships between exposures and outcomes using genome-wide association data.
- MR studies have identified potential causal associations between AD and various traits/comorbidities, including neuropsychiatric, cardiometabolic, oncologic, and immune-mediated conditions.
- Multi-omic MR approaches enable biomarker and therapeutic target discovery, aiding in drug repurposing and precision medicine.
- MR is advancing the understanding of AD and accelerating progress in precision medicine for immune-mediated diseases.