NOT-gated chimeric antigen receptor circuits in T and NK cells - PubMed
7 hours ago
- #tumor targeting
- #cancer immunotherapy
- #NOT-gated CAR
- Researchers developed NOT-gated CAR circuits combining activating (aCAR) and inhibitory (iCAR) receptors to improve cancer immunotherapy targeting.
- Over 60 circuit pairs were tested; inhibitory responses varied with aCAR's CD3ζ domain, and LIR1-iCAR reduced T cell exhaustion.
- Mechanistic studies identified SHP-1 as key regulator of LIR1-iCAR, functioning in cis.
- Circuits were successfully transferred to natural killer (NK) cells, offering a precise targeting strategy for safer, more effective therapies.