Metformin Inhibits Inflammation by Targeting the NLRP3 Inflammasome: Linking NF-κB/NEK7/AMPK Signaling to Mitochondrial Function - PubMed
4 hours ago
- #Metformin
- #NLRP3 inflammasome
- #Mitochondrial function
- Metformin, used primarily for type 2 diabetes, has notable anti-inflammatory effects beyond glucose control.
- It inhibits the NLRP3 inflammasome by affecting mitochondrial function through multiple signaling pathways, including TLR4/NF-κB, NEK7, AMPK, and JAK2-STAT.
- Key steps blocked by metformin include NEK7 assembly, ROS activation, TXNIP reduction, and caspase-1-mediated cytokine maturation.
- This action suggests metformin could treat multi-organ diseases linked to NLRP3-driven inflammation, warranting further clinical trials.