Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation - PubMed
9 hours ago
- #Vitamin D
- #Orthopaedic Health
- #Public Health
- Vitamin D is crucial for calcium-phosphate homeostasis and bone health, with additional roles in immunomodulation, neuroprotection, and anti-frailty.
- Vitamin D deficiency is linked to musculoskeletal weakness, frailty, cognitive decline, autoimmune diseases, and respiratory infections.
- Nearly half of the global population is affected by vitamin D deficiency, making it a significant public health issue.
- Effective interventions include food fortification, targeted supplementation, and optimized sun exposure.
- Vitamin D supplementation may reduce fracture and fall risks, postoperative complications, and infections, especially in orthopaedic and geriatric populations.
- Vitamin D status is relevant in managing infectious diseases, including respiratory illnesses and COVID-19.
- Challenges in existing randomized trials highlight the need for consistent dosing, appropriate formulation, and targeted populations.