Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain - PubMed
5 hours ago
- #cryo-EM
- #ion channel
- #TRPM1
- TRPM1 is essential for vision in dim light and mutations cause congenital stationary night blindness.
- The cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.
- TRPM1 has a canonical tetrameric fold in the intracellular domain but an inverted arrangement in the transmembrane domain.
- The inverted transmembrane domain forms a large pore-like structure, supporting TRPM1's role as an ion channel.
- This unique architecture may confer distinct permeation and pharmacological properties to TRPM1.