Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes - PubMed
a day ago
- #USP8
- #oocyte aneuploidy
- #spindle assembly checkpoint
- Deubiquitinase USP8 regulates the spindle assembly checkpoint (SAC) in oocytes, preventing aneuploidy.
- USP8 depletion inactivates SAC, accelerates meiotic progression, and causes abnormal spindle assembly and chromosome misalignment.
- USP8 interacts with BUB3, a key SAC component, and stabilizes it via deubiquitination.
- Exogenous BUB3 can rescue defects in USP8-depleted oocytes.
- The study reveals deubiquitination's role in SAC regulation and USP8's unique function via BUB3 interaction.