Experimental hepatitis E virus genotype 1 infection in three types of wild rodents - PubMed
3 hours ago
- #Cross-species transmission
- #Wild rodents
- #Hepatitis E virus
- HEV-1 infection demonstrated in three wild rodent species: Apodemus peninsulae, Clethrionomys rufocanus, and Lasiopodomys brandtii.
- Apodemus peninsulae showed highest susceptibility, with fecal viral shedding, systemic replication, seroconversion, and mild liver pathology.
- Intrahepatic transcriptomic analysis revealed activation of inflammatory pathways, including IL-1β and IL-18 upregulation.
- Re-inoculation confirmed protective immunity; ribavirin treatment suppressed viral replication.
- HEV-1 infection established via oral gavage, close contact, and vertical transmission.
- Study suggests wild rodents as potential hosts for HEV-1, impacting its ecology and cross-species transmission.