A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders - PubMed
5 hours ago
- #eQTL
- #brain disorders
- #single-nucleus RNA-seq
- Meta-analysis integrates snRNA-seq and genotype data from 983 individuals (5.8 million nuclei) to map eQTLs in brain cell types.
- Identifies cis- and trans-eQTLs, including disease- and sex-specific variants, with up to 10x more cis-eQTLs than bulk tissue studies.
- Reveals cell-type-specific genes linked to neurological disorders using colocalization and Mendelian randomization.
- SingleBrain resource provides insights into genetic mechanisms of brain disorders.
- Funding includes multiple NIH grants and National Research Foundation of Korea awards.