INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis - PubMed
4 hours ago
- #ADSL
- #liver cancer
- #lipogenesis
- ADSL's moonlighting function promotes INSIG1/2 succination, leading to lipogenesis and liver tumorigenesis.
- Glucose-activated PKCε phosphorylates ADSL, triggering its translocation to the endoplasmic reticulum.
- ADSL-mediated INSIG1/2 succination disrupts INSIG-SCAP interaction, activating SREBP-1 and lipogenesis-related genes.
- Elsulfavirine, an HIV drug, blocks ADSL-INSIG interaction and suppresses SREBP-1 activation.
- Combining Elsulfavirine with Lenvatinib synergistically inhibits tumor growth.
- ADSL phosphorylation and INSIG succination correlate with poor prognosis in human HCC.