Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line - PubMed
7 hours ago
- #metabolism
- #fertility
- #developmental biology
- Glycogen and lactate metabolism in mouse fetal Sertoli cells supports germ line development.
- Male-specific glycogen accumulation occurs in fetal testis between embryonic days 11.5 and 13.5.
- Blocking glycogen metabolism reduces lactate production and germ cell numbers.
- Lactate transport inhibition shows metabolic coupling between Sertoli and germ cells.
- External lactate or glucose supplementation does not rescue germ cell deficiencies.
- Glycogen accumulation is crucial during a developmental metabolic constraint window.