Neuro-immune interactions underlying autoimmune diseases: insights from brain imaging data - PubMed
5 hours ago
- #Neuro-immune interactions
- #Autoimmune diseases
- #Brain imaging
- Autoimmune diseases (AIDs) arise from complex interactions between genetic, environmental, and immune factors.
- The central nervous system (CNS) plays a significant role in the pathogenesis of AIDs.
- A study used two-sample Mendelian randomization to explore causal links between 3,935 brain imaging-derived phenotypes (IDPs) and eight AIDs.
- Nine IDPs were found to have causal associations with eight representative AIDs.
- Mediation analysis identified eight potential immune cells or inflammatory factors linking IDPs and AIDs.
- The findings highlight the CNS's involvement in autoimmune processes via neuro-immune pathways.
- The study suggests potential diagnostic and therapeutic targets within the neuro-immune axis.
- A novel framework is introduced for investigating interdisciplinary interventions targeting CNS-immune interactions in AIDs.