Spatiotemporal Organization of PTK7 Diffusion on Cell Surface Facilitates Tumor Invasion and Migration - PubMed
9 hours ago
- #tumor metastasis
- #single-molecule tracking
- #PTK7
- PTK7 diffusion modes (confined, Brownian, directed) correlate with metastatic potential in cancer cells.
- Antibody-mediated PTK7 immobilization suppresses tumor invasion, while EMT induction accelerates PTK7 diffusion to promote metastasis.
- Faster PTK7 mobility increases collision frequency with ROR2, enhancing WNT/PCP pathway activation.
- PTK7 diffusion kinetics correlate with invasive/metastatic phenotypes in patient-derived primary cells.
- Study reveals pseudokinase spatial dynamics as a biophysical regulator of tumor progression.