Longitudinal observation of severe asthma comorbidities and oral corticosteroids use from SANI and ISAR registries - PubMed
3 days ago
- #severe asthma
- #oral corticosteroids
- #comorbidities
- Longitudinal observation of severe asthma comorbidities and oral corticosteroids (OCS) use from SANI and ISAR registries.
- Higher prevalence of T2-related comorbidities (allergic rhinitis, chronic rhinosinusitis, nasal polyps) and OCS-related comorbidities in the ITALY cohort compared to ISARWORLD.
- Comorbidity-dependent patterns of biomarkers and clinical outcomes identified in both ITALY-derived and ISARWORLD cohorts.
- Progressive decrease in atopy, total IgE, exacerbations, and chronic OCS treatment, with increased lung function and eosinophils count in the SANI registry over 5 years.
- Stratification by nasal polyps, sex, and smoking status revealed additional findings like increased FeNO in nasal polyps and female cohorts, and atopic eczema in smokers.
- Changes in enrolment characteristics influenced by regional population traits, clinician attitudes, biologics availability, and OCS stewardship campaigns.