Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind
3 hours ago
- #neurodevelopment
- #vitamin B12
- #pregnancy
- Maternal vitamin B12 supplementation in vegetarian pregnant women improves infant neurodevelopment and maternal B12 status.
- The MATCOBIND trial was a double-blind, randomized controlled study conducted in India and Nepal.
- Pregnant women received either 250 µg or 50 µg of methyl-cobalamin daily from the first trimester to 6 months postpartum.
- Infants of mothers receiving 250 µg had higher mental developmental quotients (DQs) compared to those receiving 50 µg.
- Maternal vitamin B12 levels increased more significantly in the higher-dose group.
- No significant differences were found in motor DQs, newborn anthropometry, APGAR scores, or morbidity profiles between the groups.
- All infant vitamin B12 levels were within the normal range.
- The study supports higher-dose B12 supplementation for better outcomes in vegetarian mothers and their infants.