Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection - PubMed
6 days ago
- #immunodeficiency
- #HIV
- #gut microbiome
- The study examines the gut microbiome in people living with HIV (PLWH) across two geographically distinct cohorts (Israel and Ethiopia).
- Disease-specific microbial patterns were identified, including a shift from Bacteroides to Prevotella in the Israeli cohort and increased Enterobacteriaceae species in the Ethiopian cohort.
- Correlations were found between HIV-related gut dysbiosis and systemic immunodeficiency, measured by peripheral CD4+ T cell counts.
- Faecal microbiome transplantation (FMT) from PLWH with high CD4+ T cell counts increased colonic epithelium-associated CD4+ T cells in mice.
- FMT from severely immunodeficient PLWH donors led to impaired gut mucosal immunity and reduced protection against Cryptosporidium parvum infection.
- The findings suggest a link between systemic immunodeficiency, gut dysbiosis, and impaired gut immunity in PLWH.