Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders - PubMed
3 days ago
- #Psychiatric disorders
- #Clonal haematopoiesis
- #Brain white matter
- Clonal haematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of psychiatric disorders (PDs), particularly major depressive disorders and substance use disorders.
- The study involved 360,451 participants from the UK Biobank, with CHIP status determined via whole exome sequencing for mutations in 74 driver genes.
- CHIP and large CHIP (VAF ≥ 10%) were linked to a 15% and 27% increased risk of PDs, respectively, with gene-specific associations observed for seven genes (DNMT3A, TET2, ASXL1, PPM1D, SRSF2, NF1, SF3B1).
- Brain imaging-derived phenotypes (IDPs) showed significant changes in 11 white matter tracts among CHIP carriers, especially those with DNMT3A-CHIP.
- The findings suggest a biological link between CHIP and psychiatric disorders, offering new insights into disease mechanisms and potential therapeutic targets.