Dual-targeted nano-inhibitors of pyroptosis for synergistic therapy of traumatic brain injury - PubMed
3 hours ago
- #TBI therapy
- #Biomimetic nanocarriers
- #Hierarchical targeting
- Dual-targeted nano-inhibitors (TTL-NPs) deliver pyroptosis inhibitor disulfiram (DSF) for traumatic brain injury (TBI) therapy.
- TTL-NPs use endothelial cell membrane cloaking for improved blood-brain barrier (BBB) penetration.
- Hierarchical peptide engineering enables neutrophil hitchhiking in peripheral blood and subsequent neuronal targeting via Tet1 peptide after matrix metalloproteinase cleavage.
- In a murine TBI model, TTL-NPs enhanced DSF accumulation at lesion sites, suppressed pyroptosis, preserved BBB integrity, and promoted cognitive recovery.
- The strategy combines biomimetic camouflage with inflammation-responsive tiered targeting for spatiotemporal control of pyroptosis inhibition.