Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization - PubMed
3 hours ago
- #sleep deprivation
- #immunology
- #fertility
- Sleep deprivation (SD) disrupts follicular development and early embryonic potential in female mice.
- Anti-inflammatory drug acetaminophen can mitigate SD-induced ovarian damage.
- SD up-regulates neutrophil-associated genes (S100a8, S100a9), macrophage M1 polarization, and pyroptosis-related genes in ovarian cells.
- S100A8/A9 activates the TLR4/Myd88/NF-κB pathway, inducing M1 macrophage polarization and granulosa cell pyroptosis.
- Study offers insights for fertility preservation in individuals with sleep deprivation or circadian disruptions.