Microglial fructose metabolism is essential for glioblastoma growth - PubMed
5 hours ago
- #glioblastoma
- #fructose metabolism
- #microglia
- Microglial fructose metabolism is crucial for glioblastoma (GBM) growth.
- Microglia uniquely express the fructose transporter GLUT5 and are the only immune cells in the GBM microenvironment capable of metabolizing fructose.
- Global deletion of GLUT5 in mice confers resistance to tumor growth, driven by loss of fructose metabolism in microglia.
- GLUT5-deficient tumors show increased immune infiltration and activation, including enhanced antigen presentation and CD8+ T cell expansion.
- Depletion of B-cells or CD8+ T cells negates survival benefits in GLUT5 knockout mice, indicating GLUT5 suppresses adaptive immunity.
- Targeting microglial fructose metabolism may improve immunotherapeutic responses in GBM.