Systems-level organization of extracellular proteostasis - PubMed
3 hours ago
- #neurodegenerative disorders
- #extracellular proteostasis
- #protein homeostasis
- Extracellular proteostasis is organized hierarchically across pericellular, tissue, and systemic levels.
- Components include secreted chaperones, proteases, vesicles, receptors, immune sentinels, and clearance organs to manage misfolded proteins.
- Feedback mechanisms like immune signaling and fluid transport adjust capacity to proteotoxic load.
- Failures in this system contribute to neurodegenerative disorders and systemic amyloidoses.
- Potential therapies focus on stabilizing proteins, enhancing clearance, and improving fluid transport.