Adverse events associated with drug-related thiamine deficiency: A pharmacovigilance study - PubMed
4 hours ago
- #pharmacovigilance
- #thiamine deficiency
- #drug-nutrient interaction
- Thiamine deficiency can lead to severe complications like beriberi, Wernicke's encephalopathy, and Korsakoff syndrome.
- Drug-induced thiamine deficiency is an often-overlooked risk with limited systematic data.
- The study analyzed adverse events from the FDA Adverse Event Reporting System (2004-2024) using four signal detection algorithms.
- 1,046 cases of thiamine deficiency were identified, showing an increasing trend, with 46.0% requiring hospitalization.
- Median patient age was 55.0 years, 42.5% were female, and 81.5% of reports were submitted by healthcare professionals.
- The U.S. contributed the largest share of reports (27.8%).
- Top five drugs associated with thiamine deficiency: furosemide, metformin, fedratinib, metronidazole, and fluorouracil.
- 38 drugs showed consistently positive safety signals across all detection methods.
- Other notable drugs with safety signals: arsenic trioxide, torasemide, rabeprazole, and hydrochlorothiazide.
- Mechanisms may include transport inhibition and metabolic interference.
- Findings emphasize the need for clinical vigilance and thiamine monitoring in high-risk patients.