Fibronectin 1 (FN1)-rearranged Mesenchymal Neoplasms: An Updated Review - PubMed
8 hours ago
- #molecular pathology
- #FN1-rearranged neoplasms
- #mesenchymal tumors
- Fibronectin 1 (FN1) is located on chromosome 2q35 and encodes a glycoprotein in the extracellular matrix.
- FN1 rearrangements are found in various chondroid matrix-producing tumors like soft tissue chondroma and synovial chondromatosis.
- Other mesenchymal neoplasms such as lipofibromatosis and inflammatory myofibroblastic tumor also show FN1 gene fusions.
- FN1-rearranged lesions are typically classified as benign or intermediate by the WHO.
- The review updates the clinical, histological, and molecular genetic features of FN1-rearranged mesenchymal neoplasms.