Recycling senescent cell lipids for targeted senotherapy - PubMed
7 hours ago
- #lipid-recycling
- #senotherapy
- #osteoarthritis
- Senescent cells (SnCs) contribute to osteoarthritis, but conventional senolytic strategies have limitations.
- A new senotherapeutic strategy exploits SnCs' lipid metabolic signature.
- An injectable nanoliposuction hydrogel platform removes excess lipids to mitigate senescence-associated secretory phenotype (SASP) propagation.
- The harvested lipids are repurposed as part of a biomimetic lubricating system to alleviate mechanical allodynia and cartilage wear.
- This approach avoids side effects of direct SnCs clearance and repurposes harmful cells as functional resources.
- The strategy shifts senescence therapy from destructive ablation to adaptive metabolite reallocation.