Pyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart - PubMed
3 hours ago
- #mitochondrial acetylation
- #HFpEF
- #fatty acid oxidation
- HFpEF hearts exhibit mitochondrial protein hyperacetylation, particularly in fatty acid oxidation (FAO) pathways.
- Dlat, a pyruvate metabolism enzyme, acts as a key transacetylase causing mitochondrial protein hyperacetylation.
- Overexpression of Dlat increases FAO-related protein acetylation and worsens cardiac lipid metabolism, while its knockdown alleviates these effects.
- Dlat directly acetylates HADHA at K728, inactivating its enzymatic activity, linking hyperacetylation to FAO inhibition in HFpEF.
- Targeting mitochondrial protein acetylation could offer therapeutic strategies for HFpEF.