Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis - PubMe
2 hours ago
- #Longitudinal Study
- #CHG Index
- #Cardiovascular Disease
- The study investigates the association between cumulative exposure and dynamic trajectories of the Cholesterol-HDL-Glucose (CHG) index and cardiovascular disease (CVD) risk in middle-aged and older Chinese adults.
- Participants aged 45 and older were recruited from the China Health and Retirement Longitudinal Study (CHARLS), with CVD defined by self-reported descriptions.
- K-means clustering identified three distinct CHG trajectories: stable, high-risk slowly increasing, and moderate-decreasing.
- Higher cumulative CHG (cuCHG) levels were associated with increased CVD risk, with the highest quartile showing a 22% increased risk compared to the lowest quartile.
- The high-risk slowly increasing trajectory group had a significantly higher CVD risk (HR = 1.28) compared to the stable group, while the moderate-decreasing trajectory showed no significant association.
- Restricted cubic spline (RCS) analysis demonstrated a linear relationship between cuCHG and CVD risk.
- The study concludes that monitoring long-term CHG changes and maintaining stable levels may help prevent CVD in middle-aged and older adults.