ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation - PubMed
7 hours ago
- #ALKBH3
- #m1A demethylation
- #PANoptosis
- ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation.
- PANoptosis is an integrated cell death process involving pyroptosis, apoptosis, and necroptosis, contributing to cardiomyocyte loss during I/R injury.
- ALKBH3, an mRNA N1-methyladenosine (m1A) demethylase, mitigates I/R injury by inhibiting AIM2 and enhancing ZBED6 translation.
- ZBED6 interacts with STAT1 to repress STAT1-driven AIM2 expression, reducing PANoptosis.
- AIM2 knockout attenuates cardiac injury and PANoptosis exacerbated by ALKBH3 silencing.
- The study highlights the ALKBH3/ZBED6/STAT1/AIM2 axis as a therapeutic target to limit cell death and improve myocardial outcomes post-I/R.