Mechanisms of active wetting and fluidification in epithelial cell collectives - PubMed
3 hours ago
- #cell fluidity
- #IRSp53
- #epithelial cancer
- Tissue-level phase transitions play a crucial role in tumor development and metastasis.
- Epithelial tumors transition from solid-like to fluid-like states during invasion.
- IRSp53 regulates breast cancer cell fluidity by linking plasma membranes to the cytoskeleton.
- Depletion of IRSp53 increases fluidity and active wetting due to reduced intercellular friction and enhanced cell rearrangements.
- IRSp53 interacts with Afadin to control global tensile state and active wetting.
- Low IRSp53 expression and aberrant localization correlate with worse clinical outcomes in breast cancer patients.
- IRSp53-regulated mechanics have potential prognostic value in cancer.