Regulated neuronal death in Alzheimer's disease: Crosstalk and convergence of apoptosis, pyroptosis, senescence, and ferroptosis - PubMed
12 hours ago
- #Alzheimer's disease
- #neuronal death
- #neurodegeneration
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive impairment.
- Neuronal loss is a key pathological feature of AD, not fully explained by amyloid-β (Aβ) and tau proteinopathy frameworks.
- Upstream pressures like Aβ/tau proteotoxicity, mitochondrial dysfunction, oxidative stress, glucose hypometabolism, and chronic neuroinflammation trigger regulated neuronal death.
- Multiple death modalities are implicated in AD, including apoptosis, pyroptosis, cellular senescence, and ferroptosis.
- These death pathways show mixed and region-specific patterns, connected by shared hubs like oxidative stress and mitochondrial failure.
- The review discusses translational challenges, such as blood-brain barrier delivery and target specificity, and future research priorities like single-cell profiling and biomarker-guided strategies.