Melatonin Protects Mouse Oocytes From the Environmental Toxicant 6PPD-Quinone by Preserving Mitochondrial and Endomembrane Homeostasis - PubMed
3 hours ago
- #oocyte-maturation
- #melatonin
- #6PPD-Q
- 6PPD-Q, a tire-derived toxicant, impairs mouse oocyte maturation and fertilization.
- Melatonin (MT) co-treatment restores oocyte developmental outcomes affected by 6PPD-Q.
- MT mitigates 6PPD-Q-induced spindle defects, F-actin disorganization, and DNA damage.
- Transcriptomic analysis shows 6PPD-Q disrupts mitochondrial metabolism and organelle homeostasis, which MT alleviates.
- MT reduces reactive oxygen species, restores mitochondrial function, and preserves endomembrane integrity in oocytes.