Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases - PubMed
4 hours ago
- #proteomics
- #biomarkers
- #neurodegenerative diseases
- Study analyzed CSF and plasma proteomes from 2,705 and 3,009 samples across neurodegenerative diseases (AD, PD, DLB, FTD).
- CSF showed more disease-associated proteins than plasma; AD and DLB had the strongest cross-tissue molecular similarity.
- Shared immune-related dysregulation was found across diseases in both CSF and plasma.
- Disease-specific pathway disruptions included glycosylation and apoptosis in AD, ATF4/PERK signaling in PD, FGFR/interleukin signaling in DLB, and glycoprotein hormones in FTD.
- Predictive models achieved high accuracy (AUC: 0.81-0.95 in CSF, 0.80-0.89 in plasma) for disease classification.
- Findings highlight potential biomarkers and therapeutic targets for neurodegenerative diseases.