Comprehensive bioinformatic analysis reveals TRPM4 as a biomarker for pan-cancer progression and macrophage infiltration - PubMed
a day ago
- #Cancer Biomarker
- #Immunomodulation
- #Bioinformatics
- TRPM4 identified as a key biomarker for pan-cancer progression and macrophage infiltration.
- TRPM4's role varies by cancer type: risk factor in ACC, LGG, PAAD, MESO, UVM; protective in KIRP, UCEC.
- Involved in epigenetic regulation, DNA damage repair, alternative splicing, and intronic polyadenylation.
- Significant association with tumor-related signaling pathways and immunomodulatory molecules.
- Spatial co-localization with CD68+ tumor-associated macrophages suggests immunomodulatory function.
- Highlights TRPM4 as a promising therapeutic target for cancer treatment.